Medicinal Chemistry I (BP402T): Unit 2 - Adrenergic Agonists & Antagonists

PCI CBCS Syllabus Unit 2:
1. Adrenergic neurotransmitters: Biosynthesis, storage, release, and catabolism of catecholamines by MAO and COMT.
2. Adrenergic receptors: Alpha-1, Alpha-2, Beta-1, Beta-2 and Beta-3 distribution and signal transduction.
3. SAR of Adrenergic Drugs: Phenylethylamine backbone, aromatic ring substitutions, beta-hydroxyl group, and amine substitutions.
4. Direct acting: Epinephrine, Norepinephrine, Phenylephrine, Salbutamol, Terbutaline.
5. Indirect & dual acting: Ephedrine, Pseudoephedrine, Amphetamine.
6. Adrenergic blockers: Prazosin, Atenolol, Propranolol, Metoprolol, Labetalol synthesis and mechanisms.