Medicinal Chemistry I (BP402T): Unit 4 - Sedatives, Hypnotics & Antipsychotics

PCI CBCS Unit 4:
1. Mechanism of GABA-A receptor modulation and chloride conductance.
2. Barbiturates: SAR, acidic nature, synthesis of Phenobarbital and Thiopental sodium.
3. Benzodiazepines: SAR of 1,4-benzodiazepine ring, synthesis of Diazepam and Chlordiazepoxide.
4. Non-benzodiazepine hypnotics (Z-drugs): Zolpidem, Zaleplon.
5. Antipsychotics: SAR of Phenothiazines (Chlorpromazine synthesis), Thioxanthenes, and Butyrophenones (Haloperidol).