Medicinal Chemistry I (BP402T): Unit 3 - Cholinergic Drugs & Anticholinesterases

PCI CBCS Unit 3:
1. Acetylcholine: Biosynthesis, storage, release, and metabolism by Acetylcholinesterase (AChE).
2. Muscarinic receptor subtypes (M1, M2, M3) and Nicotinic receptors (Nm, Nn).
3. SAR of Parasympathomimetic agents: Modification of quaternary ammonium group, ethylene bridge (Ing's rule of five), and acyloxy group.
4. Reversible cholinesterase inhibitors: Physostigmine, Neostigmine, Pyridostigmine.
5. Irreversible organophosphates & nerve agents: Malathion, Parathion, Sarin, and Pralidoxime (2-PAM) oxime reactivation.