4th Semester • BP402T
Medicinal Chemistry I (BP402T): Unit 2 - Adrenergic Agonists & Antagonists
Compiled by Pharmacist365 Academic Council
Unit 2 • BP402T
Adrenergic Neurotransmission & SAR
Bachelor of Pharmacy (PCI CBCS) Semester IV Lecture Notes
1. Biosynthesis of Catecholamines
The biosynthesis of endogenous sympathetic neurotransmitters begins in adrenergic nerve endings from the essential dietary amino acid L-tyrosine.
$$\text{L-Tyrosine} \xrightarrow{\text{Tyrosine Hydroxylase}} \text{L-DOPA} \xrightarrow{\text{AADC}} \text{Dopamine} \xrightarrow{\text{Dopamine } \beta\text{-hydroxylase}} \text{Norepinephrine} \xrightarrow{\text{PNMT}} \text{Epinephrine}$$
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