4th Semester • BP402T
Medicinal Chemistry I (BP402T): Unit 5 - General Anesthetics & Opioid Analgesics
Compiled by Pharmacist365 Academic Council
Unit 5 • BP402T
General Anesthetics & Opioid Analgesics
Bachelor of Pharmacy (PCI CBCS) Semester IV Lecture Notes
1. Opioid Receptor Pharmacophore (Beckett-Casy Model)
The opioid receptor pharmacophore requires: (1) a flat aromatic ring for van der Waals attraction, (2) a basic nitrogen ionizable at physiological pH, and (3) an ethylene bridge connecting them to fit into an anionic cavity.
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