Industrial Pharmacy I (BP502T): Tablets, Capsules & Parenterals Technology

Chapter 1: Preformulation Studies

Preformulation testing is the initial phase in drug product development where physical, chemical, and mechanical properties of a new drug candidate are profiled.

Evaluation Parameters:

• Polymorphism: Characterization by Differential Scanning Calorimetry (DSC) and Powder X-Ray Diffraction (PXRD). Metastable polymorphs exhibit higher aqueous dissolution rates.
• Micromeritics: Particle size, Angle of Repose (\(\tan \theta = h/r\)), Carr's Compressibility Index, Hausner Ratio.